Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040816 | 1.00 | CYP11B1 (0.38) | CYP11B1CYP11B2CA2CHKAIRAK4 | |
| SCHEMBL31040771 | 0.76 | PDPK1 (0.42) | CA2CHKACHRNA7 | |
| SCHEMBL18818329 | 0.75 | NOS3 (0.47) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL18794989 | 0.74 | NOS3 (0.46) | CHRNA7 | |
| SCHEMBL27894710 | 0.74 | CHRNA7 (0.55) | CYP11B1CYP11B2CHRNA7 | |
| SCHEMBL6845118 | 0.74 | CHRNA7 (0.55) | CYP11B1CYP11B2CHRNA7 | |
| Hydrochloric Acid SCHEMBL12983298 | 0.72 | CHRNA7 (0.54) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL12983296 | 0.72 | CHRNA7 (0.54) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL31696678 | 0.71 | IDO1 (0.44) | CYP11B1CYP11B2IRAK4LOXL2 | |
| SCHEMBL15086540 | 0.69 | PNMT (0.53) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021217508-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2α AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-11-04 | — | — | WO | disclosed |