Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28030086 | 0.99 | CTSB (0.52) | CTSBCASP6ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7773858 | 0.88 | CASP6 (0.54) | CASP6ALDH1A1SMN1; SMN2ALOX5PTGES2 | |
| Hydrochloric Acid SCHEMBL28822009 | 0.87 | CASP6 (0.53) | CASP6ALDH1A1SMN1; SMN2ALOX5PTGES2 | |
| SCHEMBL28105867 | 0.87 | ALDH1A1 (0.55) | CASP6ALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL28029756 | 0.86 | ALDH1A1 (0.53) | CASP6ALDH1A1MAPTSMN1; SMN2ALOX5 | |
| SCHEMBL28105869 | 0.85 | TSHR (0.50) | CASP6ALDH1A1SMN1; SMN2ALOX5PTGES2 | |
| Hydrochloric Acid SCHEMBL28029755 | 0.84 | TSHR (0.49) | CASP6ALDH1A1SMN1; SMN2KDM4EALOX5 | |
| Hydrochloric Acid SCHEMBL4267586 | 0.84 | TSHR (0.49) | CASP6ALDH1A1SMN1; SMN2KDM4EALOX5 | |
| SCHEMBL19175109 | 0.80 | SMN1; SMN2 (0.54) | CTSBALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL1613713 | 0.80 | CTSB (0.53) | CTSBALDH1A1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210346405-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED | 2021-11-11 | — | — | US | disclosed |
| WO-2021222174-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED (US) | 2021-11-04 | — | — | WO | disclosed |
| CN-104817519-B | The derivant of one class CA-4, its preparation method and medical usage thereof | 中国药科大学 | 2016-11-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210346405-A1 | BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS | BCL2, BCL2L2, BCL2L1 | CTSB 526/4885CASP6 36/4885ALDH1A1 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.