Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.70 |
| ▸ | GCGR | P47871 | 1/20 | 0.67 |
| ▸ | MGAM | O43451 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.61 |
| ▸ | ECE1 | P42892 | 1/20 | 0.61 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.61 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.60 |
| ▸ | ALPI | P09923 | 1/20 | 0.60 |
| ▸ | ALPG | P10696 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12218568 | 0.92 | DNM1 (0.73) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL13569077 | 0.87 | RAB9A (0.94) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL19283304 | 0.86 | DNM1 (0.69) | ALDH1A1MEN1KMT2ARAB9ADNM1 | |
| SCHEMBL8771684 | 0.86 | RAB9A (0.85) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL19283303 | 0.86 | DNM1 (0.69) | ALDH1A1MEN1KMT2ARAB9ADNM1 | |
| SCHEMBL12937858 | 0.85 | GCGR (0.87) | ALDH1A1MAPTMEN1KMT2AGCGR | |
| SCHEMBL12937826 | 0.84 | ESR1 (0.78) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL12218407 | 0.83 | POLB (0.68) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL13568878 | 0.82 | RAB9A (0.97) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL13568885 | 0.82 | MAPT (0.61) | ALDH1A1MAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021225982-A1 | SOS1 ALLOSTERIC SITE TARGETING | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2021-11-11 | — | — | WO | disclosed |
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | UNIVERSITY OF CINCINNATI | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | SOS1, SOS2, SOST | ALDH1A1 4727/4885MAPT 4141/4885MEN1 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.