Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 13/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 13/20 | 0.48 |
| ▸ | ITGAL | P20701 | 13/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978784 | 0.94 | ITGB2 (0.44) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL24803375 | 0.86 | MAPT (0.48) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL30083856 | 0.86 | MAPT (0.48) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL23979004 | 0.86 | MAPT (0.48) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL23979136 | 0.83 | ITGA4 (0.38) | TDP1ITGB2ICAM1ITGAL | |
| SCHEMBL23978786 | 0.82 | ITGB2 (0.54) | ITGB2ICAM1ITGAL | |
| SCHEMBL24805463 | 0.80 | EPHX2 (0.43) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL24803486 | 0.80 | EPHX2 (0.43) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL30083840 | 0.80 | EPHX2 (0.43) | MAPTTDP1ITGB2ICAM1ITGAL | |
| SCHEMBL26503710 | 0.78 | MAPT (0.42) | MAPTTDP1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |