Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31741909 | 1.00 | SOS1 (1.00) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL17762647 | 1.00 | SOS1 (1.00) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL5440784 | 0.84 | SOS1 (0.71) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL5440780 | 0.84 | SOS1 (0.71) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL27515150 | 0.81 | SOS1 (0.68) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL14713042 | 0.80 | XDH (0.69) | SOS1MAPTALDH1A1KMT2AMAPK1 | |
| SCHEMBL11049170 | 0.80 | MAPT (0.69) | SOS1MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL9978289 | 0.80 | MAPT (0.69) | SOS1MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL14935499 | 0.80 | MAPT (0.69) | SOS1MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL446484 | 0.79 | SOS1 (0.65) | SOS1MAPTALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | UNIVERSITY OF CINCINNATI | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338694-A1 | SOS1 ALLOSTERIC SITE TARGETING | SOS1, SOS2, SOST | SOS1 1/4885MAPT 4141/4885ALDH1A1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.