Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DHPS | P49366 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978723 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL30279426 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL23978853 | 0.86 | DHPS (0.44) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL23978727 | 0.84 | DHPS (0.48) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL30279428 | 0.84 | DHPS (0.48) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL23978854 | 0.83 | DHPS (0.45) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL23978788 | 0.82 | GRM5 (0.36) | SMN1; SMN2ALDH1A1MEN1KMT2AGRM5 | |
| SCHEMBL23978808 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL30279365 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL30279364 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |