Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 9/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978787 | 0.88 | GRM5 (0.36) | GRM5EZH2AOC3KCNH2GRM2 | |
| SCHEMBL30279399 | 0.88 | GRM5 (0.36) | GRM5EZH2AOC3KCNH2GRM2 | |
| SCHEMBL23979012 | 0.84 | GRM5 (0.38) | GRM5EZH2AOC3KCNH2GRM2 | |
| SCHEMBL23978876 | 0.83 | GRM5 (0.41) | GRM5AOC3KCNH2GRM2P2RX7 | |
| SCHEMBL30279447 | 0.83 | GRM5 (0.41) | GRM5AOC3KCNH2GRM2P2RX7 | |
| SCHEMBL23978879 | 0.82 | GRM5 (0.37) | GRM5EZH2AOC3KCNH2GRM2 | |
| SCHEMBL23979086 | 0.82 | SMN1; SMN2 (0.44) | GRM5MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL23978802 | 0.71 | SMN1; SMN2 (0.32) | EZH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL30279363 | 0.71 | SMN1; SMN2 (0.32) | EZH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL23978723 | 0.70 | SMN1; SMN2 (0.52) | GRM5MEN1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |