Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978811 | 0.92 | P2RX7 (0.45) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL23978854 | 0.88 | DHPS (0.45) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL23979086 | 0.86 | SMN1; SMN2 (0.44) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL30279428 | 0.85 | DHPS (0.48) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL23978727 | 0.85 | DHPS (0.48) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL30279426 | 0.83 | SMN1; SMN2 (0.52) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL23978723 | 0.83 | SMN1; SMN2 (0.52) | DHPSGRM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL23978872 | 0.80 | P2RX7 (0.46) | DHPSSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL23978798 | 0.78 | P2RX7 (0.48) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 | |
| SCHEMBL30279386 | 0.78 | P2RX7 (0.48) | DHPSSMN1; SMN2LMNAL3MBTL1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |