SCHEMBL239795

SCHEMBL239795

O=[N+]([O-])c1cc([C@H]2CC[C@H](c3cc([N+](=O)[O-])c(Cl)cc3F)N2c2cc(F)c(N3CCC(F)(c4ccccc4)CC3)c(F)c2)c(F)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 3/20 0.35
MAPT P10636 2/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
FFAR2 O15552 2/20 0.32
GPR174 Q9BXC1 1/20 0.31
FFAR4 Q5NUL3 1/20 0.31
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL240093 0.88 KMT2A (0.39) GRM2MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL240827 0.86 FFAR4 (0.33) MAPTMEN1KMT2ASMN1; SMN2FFAR4
SCHEMBL241269 0.85 ALDH1A1 (0.37) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL240260 0.85 ALDH1A1 (0.37) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL237500 0.84 MAPT (0.39) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL241307 0.83 FFAR4 (0.32) MAPTMEN1KMT2ASMN1; SMN2FFAR4
SCHEMBL240800 0.83 HTT (0.43) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL240369 0.83 SIGMAR1 (0.35) MAPTMEN1KMT2A
SCHEMBL240305 0.83 ALDH1A1 (0.39) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1
SCHEMBL238468 0.83 ALDH1A1 (0.39) MAPTMEN1KMT2ASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
US-10039754-B2 Anti-viral compounds ABBVIE INC. (US) 2018-08-07 US disclosed
US-10028937-B2 Anti-viral compounds ABBVIE INC. (US) 2018-07-24 US disclosed
US-20170157104-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
US-20170157105-A1 Anti-Viral Compounds ABBVIE INC. (US) 2017-06-08 US disclosed
EP-2678334-B1 ANTI-VIRAL COMPOUNDS ABBVIE BAHAMAS LTD (BS) 2017-03-22 EP disclosed
US-9586978-B2 Anti-viral compounds ABBVIE INC. (US) 2017-03-07 US disclosed
EP-2692346-B1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative ABBVIE BAHAMAS LTD (BS) 2015-12-02 EP disclosed
US-20150087618-A1 Anti-Viral Compounds ABBVIE INC. (US) 2015-03-26 US disclosed
US-8937150-B2 Anti-viral compounds ABBVIE INC. (US) 2015-01-20 US disclosed
EP-2692726-A1 Anti-viral compounds Abbvie Inc. (US) 2014-02-05 EP disclosed
EP-2692346-A1 An antiviral 1-phenyl-2,5-dibenzimidazol-5-yl-pyrrolidine derivative Abbvie Inc. (US) 2014-02-05 EP disclosed
US-20120220562-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-08-30 US disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10028937-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20120220562-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20170157105-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20170157104-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20150087618-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885
US-10039754-B2 Anti-viral compounds HAVCR2, EIF2AK2, MAVS GRM2 4755/4885MAPT 2833/4885MEN1 4681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.