Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29919905 | 0.76 | NQO1 (0.67) | KDM4EALDH1A1HPGDHSD17B10NQO1 | |
| SCHEMBL8393507 | 0.76 | NQO1 (0.67) | KDM4EALDH1A1HPGDHSD17B10NQO1 | |
| SCHEMBL29862025 | 0.74 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10NQO1 | |
| SCHEMBL8391116 | 0.74 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10NQO1 | |
| SCHEMBL4937259 | 0.73 | BACE1 (0.50) | KDM4EALDH1A1HPGDHSD17B10NOS1 | |
| SCHEMBL9166541 | 0.73 | CA1 (0.46) | KDM4EALDH1A1HPGDHSD17B10HTR2A | |
| SCHEMBL23980609 | 0.72 | ADRA1A (0.47) | SLC2A1HTR2APDE10A | |
| SCHEMBL1003225 | 0.71 | NQO1 (0.72) | KDM4EALDH1A1HPGDHSD17B10NQO1 | |
| SCHEMBL20785379 | 0.71 | TAAR1 (0.64) | ALDH1A1 | |
| SCHEMBL30949381 | 0.71 | NQO1 (0.72) | KDM4EALDH1A1HPGDHSD17B10NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222542-A1 | 5-AMINO-2-PIPERIDINON-3-YL-1-OXOISOINDOLINE DERIVATIVES FOR DEGRADATION OF IKZF2 DEGRADERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |