Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710318 | 0.78 | PKM (0.43) | LMNAMEN1KMT2APKMPOLB | |
| SCHEMBL2394987 | 0.74 | LMNA (0.34) | LMNAMEN1KMT2APKM | |
| SCHEMBL1710700 | 0.74 | KMT2A (0.40) | LMNAMEN1KMT2APKMPOLB | |
| SCHEMBL2391300 | 0.73 | TGM2 (0.45) | MEN1KMT2APKMKDM4EHSD17B10 | |
| SCHEMBL2392201 | 0.72 | LMNA (0.41) | LMNA | |
| SCHEMBL2522943 | 0.71 | MEN1 (0.40) | LMNAMEN1KMT2AKDM4E | |
| SCHEMBL2398197 | 0.70 | NR1H2 (0.38) | LMNA | |
| SCHEMBL2392198 | 0.70 | EPHX2 (0.41) | LMNA | |
| SCHEMBL2394793 | 0.70 | TGM2 (0.44) | MEN1KMT2A | |
| SCHEMBL2394467 | 0.69 | EPHX2 (0.49) | LMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |