Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | CREB1 | P16220 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230092 | 0.89 | MAOB (0.50) | MAPTTDP1BCHEACHECREB1 | |
| SCHEMBL5126201 | 0.84 | CSNK2A2 (0.50) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL2398219 | 0.81 | KDM4E (0.66) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| Flavone SCHEMBL1019491 | 0.81 | CREB1 (0.73) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL14696945 | 0.74 | CYP3A4 (0.76) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL8782467 | 0.74 | TNKS (0.56) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL972006 | 0.73 | CREB1 (0.83) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL1772778 | 0.73 | HPGD (0.78) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL4157444 | 0.72 | CYP19A1 (0.63) | HPGDCYP3A4CYP2C19KDM4EMEN1 | |
| SCHEMBL4404228 | 0.72 | FYN (0.64) | HPGDCYP3A4CYP2C19KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017649-B2 | Flavonoid compounds and uses thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2011-09-13 | — | — | US | disclosed |
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | disclosed |
| EP-1856085-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | Howard Florey Institute of Experimental Physiology and Medicine (AU) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094357-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | CAT, NQO1, GPX4 | HPGD 137/4885CYP3A4 518/4885CYP2C19 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.