SCHEMBL2398706

SCHEMBL2398706

CN1C(=O)Cc2cc(-c3ccccc3-c3nc(N(C(=O)[C@@H](CC(=O)O)CC4CCCC4)C4CC4)sc3F)cnc21

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 9/20 0.51
USP19 O94966 3/20 0.31
NTRK1 P04629 3/20 0.31
USP1 O94782 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2398713 1.00 FFAR2 (0.51) FFAR2USP19NTRK1USP1
SCHEMBL1916044 0.94 FFAR2 (0.44) FFAR2NTRK1USP1
SCHEMBL1916045 0.94 FFAR2 (0.44) FFAR2NTRK1USP1
SCHEMBL1916466 0.94 FFAR2 (0.50) FFAR2USP19
SCHEMBL1916469 0.94 FFAR2 (0.45) FFAR2
SCHEMBL1916462 0.94 FFAR2 (0.50) FFAR2USP19
SCHEMBL1916473 0.94 FFAR2 (0.45) FFAR2
SCHEMBL2397936 0.93 FFAR2 (0.44) FFAR2
SCHEMBL2397941 0.93 FFAR2 (0.44) FFAR2
SCHEMBL2398591 0.92 FFAR2 (0.48) FFAR2USP19NTRK1USP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2011-09-22 US claimed
EP-2364297-A1 Compounds, pharmaceutical composition and methods for use in treating metabolic disorders Euroscreen S.A. (BE) 2011-09-14 EP claimed
WO-2010066682-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2010-06-17 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS CPT1A, LIPC, PC FFAR2 295/4885USP19 2831/4885NTRK1 4882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.