Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.49 |
| ▸ | CLK2 | P49760 | 3/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23987071 | 0.76 | DYRK1A (0.51) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL4533808 | 0.74 | SMN1; SMN2 (0.56) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30224526 | 0.74 | SMN1; SMN2 (0.56) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL24444859 | 0.72 | SMN1; SMN2 (0.50) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL26457407 | 0.72 | NPC1 (0.44) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL26493523 | 0.69 | EGFR (0.42) | — | |
| SCHEMBL27936386 | 0.68 | SMN1; SMN2 (0.53) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL23987183 | 0.67 | CLK1 (0.62) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30145000 | 0.67 | CLK1 (0.62) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL28820698 | 0.66 | SMN1; SMN2 (0.50) | CLK1DYRK1ACLK4DYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021219828-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2021-11-04 | — | — | WO | disclosed |