Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644079 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL2963197 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL30224526 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL12373172 | 0.80 | CYP2A6 (0.42) | SMN1; SMN2HTTALDH1A1NPC1RAB9A | |
| SCHEMBL27936386 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL10951998 | 0.79 | CYP2A6 (0.41) | SMN1; SMN2ALDH1A1TDP1NPC1RAB9A | |
| SCHEMBL2275595 | 0.79 | RAB9A (0.56) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL8170041 | 0.79 | KMT2A (0.47) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL14858956 | 0.78 | KEAP1 (0.59) | SMN1; SMN2HTTALDH1A1TDP1NPC1 | |
| SCHEMBL25500478 | 0.78 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143185-B1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2025-10-29 | — | — | EP | disclosed |
| US-12398129-B2 | Imidazolone derivatives as inhibitors of protein kinases in particular DYRK1A, CLK1 and/or CLK4 | PERHA PHARMACEUTICALS (FR) | 2025-08-26 | — | — | US | disclosed |
| US-20250091994-A1 | RAS/RAF BINDING INHIBITOR COMPOUND | NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) | 2025-03-20 | — | — | US | disclosed |
| WO-2025039979-A1 | PROTEIN ARGININE METHYLTRANSFERASE-5 INHIBITOR AND PHARMACEUTICAL USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2025-02-27 | — | — | WO | disclosed |
| EP-4457224-A1 | HETEROCYCLIC COMPOUNDS | BeiGene Switzerland GmbH (CH) | 2024-11-06 | — | — | EP | disclosed |
| US-20240327417-A1 | HETEROCYCLIC COMPOUNDS | BEIGENE SWITZERLAND GMBH (CH) | 2024-10-03 | — | — | US | disclosed |
| CN-118451073-A | Heterocyclic compounds | 百济神州有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-117986262-A | Condensed bicyclic compounds, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| WO-2023218023-A1 | THIAZOLOARYL-METHYL SUBSTITUTED CYCLIC HYDRAZINE-N-CARBOXAMIDE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023125681-A1 | HETEROCYCLIC COMPOUNDS | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |
| US-20100197869-A1 | Aromatic hydrogenated polymers containing fluorine | SOLVAY SOLEXIS S.P.A. (IT) | 2010-08-05 | — | — | US | disclosed |
| US-20100069275-A1 | Fluorinated lubricants | SOLVAY SOLEXIS S.P.A. (IT) | 2010-03-18 | — | — | US | disclosed |
| US-20090326154-A1 | Additives for Halopolymers | SOLVAY SOLEXIS S.P.A. (IT) | 2009-12-31 | — | — | US | disclosed |
| US-7629483-B2 | Peroxidic perfluoropolyethers | SOLVAY SOLEXIS S.P.A. (IT) | 2009-12-08 | — | — | US | disclosed |
| US-20090264406-A1 | 3-METHYL-IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | NOVARTIS AG | 2009-10-22 | — | — | US | disclosed |
| US-20080275090-A1 | AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS | BRISTOL-MYERS SQUIBB COMPANY | 2008-11-06 | — | — | US | disclosed |
| US-20080194881-A1 | Copolymers having functional end groups of sulfonyl fluorides and acyl fluorides; macromer promoters useful for both condensation and addition polymerizations for elastomers and polymershaving a crystal structure; mechanical properties; lubricants for magnetic disks; adhesives | SOLVAY SOLEXIS S.P.A. (IT) | 2008-08-14 | — | — | US | disclosed |
| US-7371900-B2 | Peroxidic perfluoropolyethers | SOLVAY SOLEXIS S.P.A. (IT) | 2008-05-13 | — | — | US | disclosed |
| US-7365229-B2 | Peroxidic perfluoropolyethers | SOLVAY SOLEXIS S.P.A. (IT) | 2008-04-29 | — | — | US | disclosed |
| WO-2002060374-A2 | BENZ-1,3-AZOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS | INSIGHT STRATEGY AND MARKETING LTD (IL) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264406-A1 | 3-METHYL-IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | MET, ERBB2, ALK | SMN1; SMN2 765/4885HTT 3764/4885ALDH1A1 973/4885 |
| US-20250091994-A1 | RAS/RAF BINDING INHIBITOR COMPOUND | BRAF, RAF1, NRAS | SMN1; SMN2 4832/4885HTT 4442/4885ALDH1A1 2352/4885 |
| US-20240327417-A1 | HETEROCYCLIC COMPOUNDS | NFATC1, CD4, ACIN1 | SMN1; SMN2 3398/4885HTT 4222/4885ALDH1A1 1006/4885 |
| US-20080194881-A1 | Copolymers having functional end groups of sulfonyl fluorides and acyl fluorides; macromer promoters useful for both condensation and addition polymerizations for elastomers and polymershaving a crystal structure; mechanical properties; lubricants for magnetic disks; adhesives | FOXO1, FOXM1, F12 | SMN1; SMN2 513/4885HTT 2792/4885ALDH1A1 1770/4885 |
| US-12398129-B2 | Imidazolone derivatives as inhibitors of protein kinases in particular DYRK1A, CLK1 and/or CLK4 | CLK1, CLK2, CLK4 | SMN1; SMN2 558/4885HTT 662/4885ALDH1A1 2571/4885 |
| US-20080275090-A1 | AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS | P2RY1, P2RY11, P2RY2 | SMN1; SMN2 3992/4885HTT 2964/4885ALDH1A1 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.