Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 20/20 | 0.51 |
| ▸ | CLK1 | P49759 | 19/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 19/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 17/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 16/20 | 0.51 |
| ▸ | CLK2 | P49760 | 16/20 | 0.51 |
| ▸ | CLK3 | P49761 | 16/20 | 0.51 |
| ▸ | DYRK4 | Q9NR20 | 16/20 | 0.51 |
| ▸ | GSK3B | P49841 | 13/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26457407 | 0.77 | NPC1 (0.44) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL23987063 | 0.76 | CLK1 (0.49) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL19140129 | 0.72 | DYRK1A (0.52) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL1418925 | 0.72 | DYRK1A (0.52) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL513882 | 0.71 | DYRK1A (0.53) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL23480179 | 0.71 | DYRK1A (0.51) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL26493523 | 0.71 | EGFR (0.42) | PIK3CDPIK3CA | |
| SCHEMBL7218352 | 0.69 | DYRK1A (0.49) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL27980410 | 0.69 | DYRK1A (0.49) | DYRK1ADYRK1BCLK1DYRK2CLK4 | |
| SCHEMBL28015693 | 0.69 | DYRK1A (0.49) | DYRK1ADYRK1BCLK1DYRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072961-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4173673-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |
| WO-2021219828-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2021-11-04 | — | — | WO | disclosed |