Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 20/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 19/20 | 0.53 |
| ▸ | CLK1 | P49759 | 19/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 17/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 16/20 | 0.46 |
| ▸ | CLK3 | P49761 | 15/20 | 0.46 |
| ▸ | DYRK4 | Q9NR20 | 15/20 | 0.46 |
| ▸ | CLK2 | P49760 | 15/20 | 0.46 |
| ▸ | GSK3B | P49841 | 14/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23480179 | 0.73 | DYRK1A (0.51) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL23987071 | 0.71 | DYRK1A (0.51) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL2881987 | 0.71 | DYRK1A (0.79) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL2881990 | 0.71 | DYRK1A (0.79) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL27980410 | 0.71 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL19140129 | 0.71 | DYRK1A (0.52) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL28015693 | 0.71 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL7218352 | 0.71 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL1418925 | 0.71 | DYRK1A (0.52) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| SCHEMBL30275520 | 0.70 | DYRK1A (0.60) | DYRK1ADYRK1BDYRK2CLK1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | DYRK1A 840/4885DYRK1B 723/4885DYRK2 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.