Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL17004744 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRCA2SMN1; SMN2 | |
| Bicarbonate SCHEMBL5003838 | 0.92 | ALDH1A1 (0.38) | ALDH1A1TSHRCA2SMN1; SMN2 | |
| Acetic Acid SCHEMBL3808838 | 0.92 | ALDH1A1 (0.41) | ALDH1A1TSHRCA2SMN1; SMN2 | |
| SCHEMBL622597 | 0.87 | — | — | |
| Bicarbonate SCHEMBL8455166 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TSHRCA2HCAR2HPGD | |
| Bicarbonate SCHEMBL28086039 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TSHRCA2HCAR2HPGD | |
| Methacrylic Acid SCHEMBL11216911 | 0.83 | ALDH1A1 (0.37) | ALDH1A1TSHR | |
| SCHEMBL1170201 | 0.79 | CA2 (0.37) | TSHRCA2 | |
| SCHEMBL6553754 | 0.79 | CA2 (0.37) | TSHRCA2 | |
| SCHEMBL9962955 | 0.79 | CA2 (0.37) | TSHRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230625-A1 | FLAME-RETARDANT POLYESTER RESIN COMPOSITION | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20110229673-A1 | FLAME-RETARDANT POLYESTER RESIN COMPOSITION AND BLOW MOLDED CONTAINER | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2011-09-22 | — | — | US | disclosed |