Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.68 |
| ▸ | ABL1 | P00519 | 10/20 | 0.68 |
| ▸ | EGFR | P00533 | 10/20 | 0.68 |
| ▸ | MTOR | P42345 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.68 |
| ▸ | FYN | P06241 | 4/20 | 0.68 |
| ▸ | YES1 | P07947 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.68 |
| ▸ | LYN | P07948 | 2/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | INSR | P06213 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30782445 | 0.89 | NUDT14 (0.69) | SRCABL1EGFRMTORKDR | |
| SCHEMBL12366 | 0.89 | NUDT14 (0.69) | SRCABL1EGFRMTORKDR | |
| SCHEMBL16886112 | 0.87 | PIK3CD (0.68) | SRCABL1EGFRMTORKDR | |
| SCHEMBL13019672 | 0.87 | SRC (0.69) | SRCABL1EGFRMTORKDR | |
| SCHEMBL130419 | 0.87 | PIK3CD (0.70) | SRCABL1EGFRMTORKDR | |
| SCHEMBL23917243 | 0.87 | KDM4E (0.69) | SRCABL1EGFRMTORKDR | |
| SCHEMBL21079131 | 0.87 | NUDT14 (0.66) | SRCABL1EGFRMTORKDR | |
| SCHEMBL409367 | 0.86 | PIK3CD (0.82) | SRCABL1EGFRMTORKDR | |
| SCHEMBL23917506 | 0.85 | NUDT14 (0.64) | SRCABL1EGFRMTORKDR | |
| SCHEMBL13826048 | 0.84 | NUDT14 (0.63) | SRCABL1EGFRMTORKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151525-A9 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012151525-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-08 | — | — | WO | disclosed |
| WO-2009062118-A2 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |