Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 3/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | CA7 | P43166 | 3/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.59 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.59 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707094 | 0.93 | CA12 (0.67) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL8041186 | 0.91 | CA12 (0.65) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL24012957 | 0.86 | CES2 (0.52) | NPC1RAB9AMEN1KMT2ACES2 | |
| SCHEMBL23998049 | 0.86 | CES2 (0.52) | NPC1RAB9AMEN1KMT2ACES2 | |
| SCHEMBL28290879 | 0.86 | CA12 (0.59) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL570100 | 0.85 | ADRB2 (0.52) | NPC1RAB9AMEN1KMT2ACES2 | |
| SCHEMBL13229042 | 0.84 | CA12 (0.57) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL6653048 | 0.84 | CA12 (0.68) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL16687595 | 0.84 | CA12 (0.57) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL12806511 | 0.83 | CES2 (0.49) | NPC1RAB9AMEN1KMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183164-A1 | Synthesis of Vinyl Cyclobutyl Intermediates | AMGEN INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230183164-A1 | Synthesis of Vinyl Cyclobutyl Intermediates | AMGEN INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230174496-A1 | Synthesis of Vinylic Protected Alcohol Intermediates | AMGEN INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174496-A1 | Synthesis of Vinylic Protected Alcohol Intermediates | AMGEN INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230167130-A1 | Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates | AMGEN INC. (US) | 2023-06-01 | — | — | US | disclosed |
| US-20230167130-A1 | Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates | AMGEN INC. (US) | 2023-06-01 | — | — | US | disclosed |
| WO-2021225823-A1 | SYNTHESIS OF VINYLIC PROTECTED ALCOHOL INTERMEDIATES | AMGEN INC. (US) | 2021-11-11 | — | — | WO | disclosed |
| CN-105873911-B | Thiazolium compounds and its Pesticidal purposes | 住友化学株式会社 | 2018-07-24 | — | — | CN | disclosed |
| CN-105873911-A | Thiazole compounds and pest control applications thereof | 住友化学株式会社 | 2016-08-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174496-A1 | Synthesis of Vinylic Protected Alcohol Intermediates | MCL1, BCL2A1, BAK1 | NPC1 988/4885RAB9A 3039/4885MEN1 43/4885 |
| US-20230183164-A1 | Synthesis of Vinyl Cyclobutyl Intermediates | MCL1, BCL2A1, BAK1 | NPC1 1467/4885RAB9A 4339/4885MEN1 33/4885 |
| US-20230167130-A1 | Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates | MCL1, BAK1, BCLAF1 | NPC1 1131/4885RAB9A 3878/4885MEN1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.