Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fentanyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.70 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
| ▸ | HRH1 | P35367 | 1/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenoperidine SCHEMBL3992197 | 0.89 | OPRM1 (0.61) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Anileridine SCHEMBL16339975 | 0.85 | OPRM1 (0.56) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL8804 | 0.84 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL916599 | 0.84 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL4971300 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL18249370 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL22637301 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL4321837 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL4324385 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL28383546 | 0.83 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110217383-A1 | PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL OPIOID COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL | EVONIK ROEHM GMBH | 2011-09-08 | — | — | US | claimed |
| EP-3742960-A1 | SYSTEMS, DEVICES, AND METHODS TO COMPENSATE FOR TEMPERATURE EFFECTS ON SENSORS | Dexcom, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019147582-A1 | SYSTEMS, DEVICES, AND METHODS TO COMPENSATE FOR TEMPERATURE EFFECTS ON SENSORS | DEXCOM, INC. (US) | 2019-08-01 | — | — | WO | disclosed |