Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenoperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentanyl SCHEMBL2400317 | 0.89 | OPRM1 (0.70) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Phenoperidine SCHEMBL80415 | 0.82 | KCNA3 (0.83) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Phenoperidine SCHEMBL28832646 | 0.82 | KCNA3 (0.67) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Phenoperidine SCHEMBL394330 | 0.81 | KCNA3 (0.81) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Anileridine SCHEMBL16339975 | 0.81 | OPRM1 (0.56) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Phenoperidine SCHEMBL1652634 | 0.81 | KCNA3 (0.80) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL8804 | 0.78 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Pheneridine SCHEMBL1922392 | 0.78 | KCNA3 (0.86) | OPRM1OPRD1OPRK1SLC22A1ADRA1A | |
| Fentanyl SCHEMBL916599 | 0.78 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL22637301 | 0.78 | OPRM1 (0.98) | OPRM1OPRD1OPRK1SLC22A1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063872-B1 | CONTROLLED RELEASE ORAL DOSAGE FORMULATIONS COMPRISING A CORE AND ONE OR MORE BARRIER LAYERS | JAGOTEC AG (CH) | 2015-05-06 | — | — | EP | disclosed |
| EP-2063872-A1 | CONTROLLED RELEASE ORAL DOSAGE FORMULATIONS COMPRISING A CORE AND ONE OR MORE BARRIER LAYERS | Jagotec AG (CH) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008025535-A1 | CONTROLLED RELEASE ORAL DOSAGE FORMULATIONS COMPRISING A CORE AND ONE OR MORE BARRIER LAYERS | JAGOTEC AG (CH) | 2008-03-06 | — | — | WO | disclosed |
| US-5213808-A | Drug delivery | BUHK MEDITEC A/A (DK) | 1993-05-25 | — | — | US | disclosed |