Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anileridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.56 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentanyl SCHEMBL2400317 | 0.85 | OPRM1 (0.70) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL6908995 | 0.84 | OPRM1 (0.80) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL40733 | 0.84 | OPRM1 (0.80) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL193602 | 0.84 | OPRM1 (0.80) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL216836 | 0.84 | OPRM1 (0.80) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL6002326 | 0.84 | OPRM1 (0.80) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL27481710 | 0.83 | OPRM1 (0.78) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL19066928 | 0.83 | OPRM1 (0.78) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Fentanyl SCHEMBL2722646 | 0.82 | OPRM1 (0.74) | OPRM1OPRD1SLC22A1NR1I2ABCB1 | |
| Phenoperidine SCHEMBL3992197 | 0.81 | OPRM1 (0.61) | OPRM1OPRD1SLC22A1NR1I2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3043795-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-07-20 | — | — | EP | disclosed |
| EP-3013338-A1 | USE OF SIGMA RECEPTOR LIGANDS FOR THE PREVENTION AND TREATMENT OF PAIN ASSOCIATED TO INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME (IC/BPS) | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-05-04 | — | — | EP | disclosed |
| WO-2015036470-A1 | NSAID AND SIGMA RECEPTOR LIGAND COMBINATIONS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2015-03-19 | — | — | WO | disclosed |
| WO-2014207024-A1 | USE OF SIGMA RECEPTOR LIGANDS FOR THE PREVENTION AND TREATMENT OF PAIN ASSOCIATED TO INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME (IC/BPS) | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-12-31 | — | — | WO | disclosed |