Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19820203 | 0.80 | KLKB1 (0.43) | CDK8KDRFGFR1PIK3CAAXL | |
| SCHEMBL24005747 | 0.75 | CDK8 (0.39) | MAP4K1DHFRCDK8DYRK1AKDR | |
| SCHEMBL24005901 | 0.74 | PIK3CA (0.36) | MAP4K1DHFRCDK8DYRK1AKDR | |
| SCHEMBL1680373 | 0.72 | NUDT1 (0.52) | — | |
| SCHEMBL18129582 | 0.72 | CSNK2A1 (0.40) | DHFRCDK8DYRK1AKDRRIPK1 | |
| SCHEMBL24005537 | 0.71 | PIK3CA (0.37) | MAP4K1DHFRCDK8DYRK1AKDR | |
| SCHEMBL25613108 | 0.71 | ULK1 (0.39) | MAP4K1DHFRCDK8DYRK1AKDR | |
| SCHEMBL16246983 | 0.71 | CDK8 (0.40) | MAP4K1DHFRCDK8KDRFGFR1 | |
| SCHEMBL25469833 | 0.71 | FGFR1 (0.33) | CDK8KDRFGFR1 | |
| SCHEMBL4151886 | 0.70 | PTPRC (0.44) | MAP4K1CDK8KDRRIPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |