Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 5/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25625193 | 0.77 | ULK1 (0.36) | CDK8CA1CA2BRAFALOX5AP | |
| SCHEMBL24005537 | 0.73 | PIK3CA (0.37) | CDK8KDM5BPIK3CA | |
| SCHEMBL12146427 | 0.72 | CDK8 (0.36) | CDK8KDM5BPIK3CA | |
| SCHEMBL24005526 | 0.70 | CDK8 (0.35) | CDK8KDM5BPIK3CA | |
| SCHEMBL19367715 | 0.68 | CDK8 (0.34) | CDK8FEN1KDM5BPIK3CA | |
| SCHEMBL25624524 | 0.68 | CDK8 (0.34) | CDK8KDM5BPIK3CA | |
| SCHEMBL25650901 | 0.67 | CDK8 (0.44) | CDK8 | |
| SCHEMBL24005918 | 0.65 | NR3C1 (0.44) | CDK8BRAFALOX5APFEN1TNNI3K | |
| SCHEMBL25650900 | 0.65 | LPAR1 (0.33) | CDK8 | |
| SCHEMBL25626044 | 0.64 | NR3C1 (0.43) | CDK8ALOX5APFEN1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |