Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398541 | 0.83 | CDK8 (0.46) | CDK8NPSR1ABL1KDM4EALDH1A1 | |
| SCHEMBL20551884 | 0.83 | CDK8 (0.46) | CDK8NPSR1ABL1KITKDR | |
| SCHEMBL30452148 | 0.83 | CDK8 (0.46) | CDK8NPSR1ABL1KITKDR | |
| SCHEMBL25613170 | 0.80 | CDK8 (0.44) | CDK8NPSR1ABL1KITKDR | |
| SCHEMBL25650901 | 0.80 | CDK8 (0.44) | CDK8NPSR1ABL1KITKDR | |
| SCHEMBL30675159 | 0.78 | KDM4E (0.41) | CDK8NPSR1ABL1KDM4EALDH1A1 | |
| SCHEMBL21060155 | 0.78 | KDM4E (0.41) | CDK8NPSR1ABL1KDM4EALDH1A1 | |
| SCHEMBL4792436 | 0.77 | CDK8 (0.47) | CDK8KDRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31497493 | 0.73 | CHEK1 (0.50) | CDK8ABL1KDRKDM4ESMN1; SMN2 | |
| SCHEMBL4793467 | 0.73 | CDK8 (0.46) | CDK8NPSR1ABL1KDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |