Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | FES | P07332 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20551884 | 1.00 | CDK8 (0.46) | CDK8CHEK1NPSR1TTBK1TTBK2 | |
| SCHEMBL24005756 | 0.83 | CDK8 (0.47) | CDK8CHEK1NPSR1ABL1SMN1; SMN2 | |
| SCHEMBL20553146 | 0.82 | ALDH1A1 (0.39) | CDK8SMN1; SMN2KDRPLK4DCLK1 | |
| SCHEMBL31398541 | 0.81 | CDK8 (0.46) | CDK8CHEK1NPSR1ABL1SMN1; SMN2 | |
| SCHEMBL20552180 | 0.79 | MMP2 (0.40) | CDK8CHEK1NPSR1TTBK1TTBK2 | |
| SCHEMBL25613170 | 0.79 | CDK8 (0.44) | CDK8CHEK1NPSR1ABL1KDR | |
| SCHEMBL25650901 | 0.79 | CDK8 (0.44) | CDK8CHEK1NPSR1TTBK1TTBK2 | |
| SCHEMBL20552070 | 0.76 | AXL (0.44) | NPSR1SMN1; SMN2XDHROCK2ROCK1 | |
| SCHEMBL27388937 | 0.75 | MAP4K1 (0.48) | NPSR1ABL1SMN1; SMN2XDHKDM4E | |
| SCHEMBL20551388 | 0.74 | NPSR1 (0.40) | NPSR1ABL1SMN1; SMN2XDHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024222677-A1 | WRN INHIBITOR | 苏州浦合医药科技有限公司 | 2024-10-31 | — | — | WO | disclosed |
| CN-116270660-A | Bcl-2/Bcl-xl inhibitor-containing composition and preparation method and application thereof | 广州麓鹏制药有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116236583-A | Bcl-2/Bcl-xl inhibitor-containing composition and preparation method and application thereof | 广州麓鹏制药有限公司 | 2023-06-09 | — | — | CN | disclosed |