Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.35 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24005743 | 0.83 | CDK8 (0.40) | FGFR1KDRBRD4AXLCDK8 | |
| SCHEMBL24005744 | 0.81 | CNR2 (0.41) | FGFR1KDRBRD4AXLCDK8 | |
| SCHEMBL24005535 | 0.81 | BRD4 (0.43) | FGFR1KDRNUDT1BRD4AXL | |
| SCHEMBL24005746 | 0.80 | HTR7 (0.39) | FGFR1KDR | |
| SCHEMBL25613037 | 0.80 | FEN1 (0.39) | FGFR1KDRNUDT1BRD4AXL | |
| SCHEMBL5823323 | 0.78 | NUDT1 (0.54) | KDRNUDT1 | |
| SCHEMBL24005909 | 0.78 | TLR7 (0.34) | FGFR1KDRBRD4AXLCDK8 | |
| SCHEMBL24005740 | 0.78 | JAK3 (0.41) | FGFR1KDRBRD4PIK3CD | |
| SCHEMBL6493825 | 0.77 | NUDT1 (0.41) | KDRNUDT1CDK8LRRK2 | |
| SCHEMBL24005765 | 0.76 | LTA4H (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021223736-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |