SCHEMBL2400730

SCHEMBL2400730

CN(C(=O)C(CC(=O)O)CC1CCCC1)c1nc(-c2cc(Cl)ccc2-c2cnc3c(c2)CC(=O)N3C)cs1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 11/20 0.58
UCHL1 P09936 2/20 0.33
USP30 Q70CQ3 1/20 0.33
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
CNR1 P21554 1/20 0.32
GRM1 Q13255 1/20 0.31
DHODH Q02127 1/20 0.31
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TYR P14679 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2400725 1.00 FFAR2 (0.58) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL1916532 0.94 FFAR2 (0.59) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL1916536 0.94 FFAR2 (0.59) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL2399167 0.94 FFAR2 (0.57) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL2399171 0.94 FFAR2 (0.57) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL2399421 0.93 FFAR2 (0.54) FFAR2GRM1
SCHEMBL2399425 0.93 FFAR2 (0.54) FFAR2GRM1
SCHEMBL2052730 0.92 FFAR2 (0.62) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL2052731 0.92 FFAR2 (0.62) FFAR2UCHL1USP30NPC1RAB9A
SCHEMBL2398004 0.92 FFAR2 (0.58) FFAR2CNR1TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2011-09-22 US claimed
EP-2364297-A1 Compounds, pharmaceutical composition and methods for use in treating metabolic disorders Euroscreen S.A. (BE) 2011-09-14 EP claimed
WO-2010066682-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2010-06-17 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS CPT1A, LIPC, PC FFAR2 295/4885UCHL1 3346/4885USP30 3824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.