Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770329 | 0.82 | SMN1; SMN2 (0.46) | KMT2AALDH1A1TP53MITFMEN1 | |
| SCHEMBL1833452 | 0.76 | MCL1 (0.46) | MCL1KMT2ATP53MEN1USP2 | |
| SCHEMBL923978 | 0.73 | ALDH1A1 (0.48) | KMT2AALDH1A1TP53MITFMEN1 | |
| SCHEMBL1120133 | 0.71 | MCL1 (0.42) | MCL1KMT2ATP53MEN1USP2 | |
| SCHEMBL22109258 | 0.70 | ALDH1A1 (0.46) | KMT2AALDH1A1TP53MITFMEN1 | |
| SCHEMBL24816445 | 0.65 | ALDH1A1 (0.39) | KMT2AALDH1A1TP53MITFMEN1 | |
| SCHEMBL24008018 | 0.65 | MCL1 (0.31) | MCL1 | |
| SCHEMBL13206417 | 0.65 | ALOX15 (0.40) | MCL1TP53SMN1; SMN2HPGDALOX15 | |
| SCHEMBL24007363 | 0.65 | MCL1 (0.44) | MCL1KMT2AALDH1A1TP53MEN1 | |
| SCHEMBL18343615 | 0.65 | MCL1 (0.38) | MCL1KMT2AALDH1A1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2021226261-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |