Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011198 | 0.90 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL26633914 | 0.90 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011436 | 0.87 | SMN1; SMN2 (0.63) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011437 | 0.87 | SMN1; SMN2 (0.63) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011481 | 0.85 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011062 | 0.84 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011431 | 0.84 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011556 | 0.84 | ACHE (0.49) | SMN1; SMN2ACHEBACE1ALDH1A1POLB | |
| SCHEMBL24011294 | 0.83 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011344 | 0.83 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | NAMPT, NNT, NAPRT | NPC1 128/4885RAB9A 814/4885SMN1; SMN2 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.