Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011270 | 0.85 | PKM (0.45) | ALDH1A1 | |
| SCHEMBL24011342 | 0.84 | NPC1 (0.57) | ACHEBACE1ALDH1A1POLBMEN1 | |
| SCHEMBL24011567 | 0.83 | PKM (0.43) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24011627 | 0.82 | MEN1 (0.46) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24011251 | 0.81 | ADAM17 (0.47) | ALDH1A1 | |
| SCHEMBL24011413 | 0.80 | PKM (0.39) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL24011682 | 0.78 | PRKAB2 (0.56) | ALDH1A1POLBMEN1KMT2AGAA | |
| SCHEMBL24011561 | 0.78 | THRB (0.57) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24011323 | 0.77 | HRH1 (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL26633914 | 0.76 | NPC1 (0.51) | ACHEBACE1ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |