Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402029 | 0.87 | CNR1 (0.55) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2402023 | 0.87 | CNR1 (0.55) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2405216 | 0.84 | MEN1 (0.47) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2405219 | 0.84 | MEN1 (0.47) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2405890 | 0.84 | MEN1 (0.47) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2400297 | 0.84 | MEN1 (0.50) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2400299 | 0.84 | MEN1 (0.50) | ALDH1A1HRH3MEN1KMT2ACNR1 | |
| SCHEMBL2403512 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HRH3CHRM1MEN1KMT2A | |
| SCHEMBL2402137 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HRH3CHRM1MEN1KMT2A | |
| SCHEMBL2401399 | 0.83 | DRD2 (0.51) | ALDH1A1HRH3MEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017773-B2 | Cyclohexyl sulfonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | disclosed |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120791-A1 | CYCLOHEXYL SULFONAMIDE DERIVATIVES | HRH3, HRH4, HRH1 | ALDH1A1 430/4885HRH3 1/4885CHRM1 67/4885 |
| US-20070173511-A1 | Cyclohexyl sulfonamide derivatives | HRH3, HRH4, HRH1 | ALDH1A1 430/4885HRH3 1/4885CHRM1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.