Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CALML3 | P27482 | 1/20 | 0.31 |
| ▸ | SDHA | P31040 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | ENGASE | Q8NFI3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015545 | 1.00 | MTNR1A (0.32) | MTNR1AMTNR1BCACNA1HPIK3CDFUCA1 | |
| SCHEMBL25587347 | 0.83 | RIPK1 (0.34) | — | |
| SCHEMBL25587349 | 0.83 | RIPK1 (0.34) | — | |
| SCHEMBL26198187 | 0.83 | RIPK1 (0.34) | — | |
| SCHEMBL3394009 | 0.74 | NPC1 (0.43) | MTNR1AMTNR1BCACNA1HPIK3CDFUCA1 | |
| SCHEMBL12512570 | 0.73 | LMNA (0.37) | MTNR1AMTNR1BCACNA1HLMNA | |
| SCHEMBL25608140 | 0.71 | FUCA1 (0.36) | MTNR1AMTNR1BCACNA1HFUCA1SLC6A2 | |
| SCHEMBL10106984 | 0.71 | CYP2C9 (0.49) | MTNR1AMTNR1BCACNA1HFUCA1GLA | |
| SCHEMBL1901026 | 0.70 | FUCA1 (0.39) | MTNR1AMTNR1BCACNA1HFUCA1GLA | |
| SCHEMBL25097716 | 0.68 | POLB (0.38) | MTNR1AMTNR1BCACNA1HFUCA1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |