Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.47 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | GRK2 | P25098 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016565 | 0.91 | MEN1 (0.55) | ALDH1A1LMNATEAD1TEAD4TEAD2 | |
| SCHEMBL24016615 | 0.90 | ROCK2 (0.48) | ALDH1A1LMNAROCK2MEN1KMT2A | |
| SCHEMBL24016561 | 0.89 | TEAD1 (0.44) | ALDH1A1LMNATEAD1TEAD4TEAD2 | |
| SCHEMBL24015695 | 0.87 | TEAD1 (0.49) | TEAD1TEAD4TEAD2TEAD3RORC | |
| SCHEMBL24016533 | 0.87 | TEAD1 (0.45) | ALDH1A1LMNATEAD1TEAD4TEAD2 | |
| SCHEMBL24016023 | 0.87 | PPARG (0.53) | ALDH1A1LMNATEAD1TEAD4TEAD2 | |
| SCHEMBL24015697 | 0.86 | TEAD1 (0.48) | ALDH1A1TEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL24016489 | 0.86 | TEAD1 (0.48) | TEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL24016576 | 0.85 | TEAD1 (0.53) | TEAD1TEAD4TEAD2TEAD3RORC | |
| SCHEMBL24016304 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNATEAD1TEAD4TEAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |