Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.44 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.44 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015671 | 0.91 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24016249 | 0.86 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL24016185 | 0.85 | TEAD1 (0.63) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL24016023 | 0.85 | PPARG (0.53) | MEN1KMT2AALDH1A1LMNASORT1 | |
| SCHEMBL30561352 | 0.84 | ALDH1A1 (0.56) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL25381780 | 0.84 | ALDH1A1 (0.56) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL24016561 | 0.84 | TEAD1 (0.44) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL24015695 | 0.83 | TEAD1 (0.49) | MAPTTEAD1TEAD4TEAD2TEAD3 | |
| SCHEMBL24016533 | 0.83 | TEAD1 (0.45) | MAPTALDH1A1LMNATEAD1TEAD4 | |
| SCHEMBL24015697 | 0.82 | TEAD1 (0.48) | MAPTALDH1A1TEAD1TEAD4TEAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |