SCHEMBL24017285

SCHEMBL24017285

COC(=O)c1cc(Br)cc(OC(F)(F)C(F)F)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.57
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
TRPV1 Q8NER1 1/20 0.40
MAPT P10636 4/20 0.39
CA12 O43570 1/20 0.39
CA14 Q9ULX7 1/20 0.39
LMNA P02545 2/20 0.38
KDM4E B2RXH2 2/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
NFKB1 P19838 1/20 0.38
XDH P47989 1/20 0.38
GFER P55789 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
FUT7 Q11130 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1868624 0.88 NOTUM (0.64) NOTUMCA1CA2CA7CA9
SCHEMBL31401414 0.88 NOTUM (0.64) NOTUMCA1CA2CA7CA9
SCHEMBL30293918 0.84 NOTUM (0.59) NOTUMCA1CA2CA7CA9
SCHEMBL26616653 0.84 NOTUM (0.59) NOTUMCA1CA2CA7CA9
SCHEMBL34467289 0.83 ALDH1A1 (0.46) NOTUMCA1CA2CA7CA9
SCHEMBL24017411 0.83 ALDH1A1 (0.46) NOTUMCA1CA2CA7CA9
SCHEMBL28987542 0.81 NOTUM (0.56) NOTUMCA1CA2CA7CA9
SCHEMBL29672158 0.80 NOTUM (0.54) NOTUMCA1CA2CA7CA9
SCHEMBL20944192 0.80 NOTUM (0.54) NOTUMCA1CA2CA7CA9
SCHEMBL29283387 0.79 NOTUM (0.40) NOTUMCA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12612386-B2 Heteroaryl-triazole compounds as pesticides BAYER AKTIENGESELLSCHAFT (DE) 2026-04-28 US disclosed
EP-4146643-B1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2024-05-29 EP disclosed
US-20230348432-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2023-11-02 US disclosed
US-20230348432-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2023-11-02 US disclosed
US-20230348432-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2023-11-02 US disclosed
CN-115996639-A Novel heteroaryl-triazole compounds as pesticides 拜耳公司 2023-04-21 CN disclosed
EP-4146643-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES Bayer Aktiengesellschaft (DE) 2023-03-15 EP disclosed
WO-2021224323-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2021-11-11 WO disclosed
WO-2021224323-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2021-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348432-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES CYP4F3, CYP4X1, GLRX3 NOTUM 1858/4885CA1 4440/4885CA2 3769/4885
US-12612386-B2 Heteroaryl-triazole compounds as pesticides CBR3, CYCS, HCN1 NOTUM 2255/4885CA1 823/4885CA2 552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.