Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.67 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | TACR1 | P25103 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20809260 | 1.00 | OPRM1 (0.67) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| Bromide SCHEMBL1616477 | 0.99 | CYP3A4 (0.68) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| Oxalic Acid SCHEMBL20797723 | 0.95 | OPRD1 (0.64) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| Oxalic Acid SCHEMBL30550905 | 0.95 | OPRD1 (0.64) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2404294 | 0.90 | OPRK1 (0.65) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| Bromide SCHEMBL1617682 | 0.89 | CYP3A4 (0.66) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13383292 | 0.89 | GRIN2D (0.77) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3274740 | 0.89 | GRIN2D (0.77) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL24796554 | 0.89 | OPRM1 (0.61) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2420917 | 0.89 | OPRM1 (0.61) | OPRM1OPRK1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110243889-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | JENKEN BIOSCIENCES, INC. | 2011-10-06 | — | — | US | claimed |
| US-9776971-B2 | Opioid and opioid-like compounds and uses thereof | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2017-10-03 | — | — | US | disclosed |
| US-20120114599-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | JENKEN BIOSCIENCES, INC. | 2012-05-10 | — | — | US | disclosed |
| US-8017622-B2 | Opioid and opioid-like compounds and uses thereof | JENKEN BIOSCIENCES, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20090169508-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | JENKIN BIOSCIENCES, INC. | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114599-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | OPRK1, OPRL1, OPRM1 | OPRM1 3/4885OPRK1 1/4885GRIN2D 962/4885 |
| US-20090169508-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | OPRK1, OPRL1, OPRM1 | OPRM1 3/4885OPRK1 1/4885GRIN2D 962/4885 |
| US-20110243889-A1 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRK1 2/4885GRIN2D 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.