Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351667 | 0.86 | KDM4E (0.45) | TGM2PIP4K2APIP4K2BRAB9ANPC1 | |
| SCHEMBL23336395 | 0.83 | PIP4K2A (0.36) | PIP4K2APIP4K2BSMN1; SMN2KMT2AEGFR | |
| SCHEMBL16665103 | 0.82 | NMT1 (0.58) | POLBTGM2PIP4K2APIP4K2BRAB9A | |
| SCHEMBL18722598 | 0.74 | TGM2 (0.50) | POLBTGM2RAB9ANPC1KMT2A | |
| SCHEMBL21781161 | 0.70 | TGM2 (0.46) | POLBTGM2RAB9ANPC1KMT2A | |
| SCHEMBL23997975 | 0.70 | KDM4E (0.36) | — | |
| SCHEMBL13389249 | 0.70 | EGFR (0.55) | TGM2PIP4K2APIP4K2BRAB9ANPC1 | |
| SCHEMBL10057892 | 0.69 | TDP1 (0.60) | POLBTGM2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27291660 | 0.69 | TAAR1 (0.39) | POLBTGM2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20764166 | 0.69 | CDK14 (0.47) | PIP4K2APIP4K2BRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |