Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 13/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568918 | 0.85 | MGLL (0.49) | MGLLSMN1; SMN2CHRM2CHRM3 | |
| SCHEMBL22790691 | 0.85 | MGLL (0.41) | MGLLSMN1; SMN2CHRM2CHRM3 | |
| SCHEMBL29646242 | 0.85 | S1PR1 (0.41) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL25887901 | 0.83 | L3MBTL1 (0.47) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL25829095 | 0.83 | MGLL (0.45) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL29646165 | 0.82 | S1PR1 (0.39) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL23945989 | 0.80 | MGLL (0.43) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL26404934 | 0.80 | MGLL (0.40) | MGLLS1PR1S1PR3S1PR5S1PR4 | |
| SCHEMBL23806770 | 0.77 | MGLL (0.47) | MGLLCHRM2CHRM3 | |
| SCHEMBL26408514 | 0.76 | MGLL (0.44) | MGLLCHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2021231778-A1 | CORONAVIRUS PROTEASE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |