Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 11/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27560148 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL1238140 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL499484 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL63810 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL1979606 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL5822456 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL4949804 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8418674 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL20487518 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL27731205 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924548-B1 | ESTER PRODRUGS OF PROSTRATIN AND RELATED PHORBOL COMPOUNDS | SALVIA SCIENCES INC (US) | 2018-03-28 | — | — | EP | disclosed |
| US-8431612-B2 | Ester prodrugs of prostratin and related phorbol compounds | SALVIA SCIENCES, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20110251421-A1 | Ester Prodrugs of Prostratin and Related Phorbol Compounds | SALVIA SCIENCES, INC. (US) | 2011-10-13 | — | — | US | disclosed |
| US-8022103-B2 | Ester prodrugs of prostratin and related phorbol compounds | SALVIA SCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090163587-A1 | ESTER PRODRUGS OF PROSTRATIN AND RELATED PHORBOL COMPOUNDS | SALVIA SCIENCES, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| EP-1924548-A2 | ESTER PRODRUGS OF PROSTRATIN AND RELATED PHORBOL COMPOUNDS | Salvia Sciences, Inc. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007009055-A2 | ESTER PRODRUGS OF PROSTRATIN AND RELATED PHORBOL COMPOUNDS | SALVIA SCIENCES, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
| US-4212982-A | Polyisocyanates with at least one hydantoin or thiohydantoin ring substituted by carboxylic acid amide groups | BAYER AKTIENGESELLSCHAFT (DE) | 1980-07-15 | — | — | US | disclosed |
| US-3904628-A | NOVEL CYCLOALKANOL FUMARATE ETHERS AND A PROCESS FOR THE PREPARATION THEREOF | EGYT GYOGYSZERVEGYESZETI GYAR | 1975-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251421-A1 | Ester Prodrugs of Prostratin and Related Phorbol Compounds | PMAIP1, PTGIR, PTGDR | HCAR2 164/4885TSHR 1604/4885TP53 205/4885 |
| US-20090163587-A1 | ESTER PRODRUGS OF PROSTRATIN AND RELATED PHORBOL COMPOUNDS | PMAIP1, PTGIR, PTGDR | HCAR2 104/4885TSHR 946/4885TP53 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.