Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 11/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27560148 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL1238140 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL499484 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL63810 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL1979606 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL5822456 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8418674 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL2402992 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL20487518 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL27731205 | 1.00 | HCAR2 (0.60) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3813835-A1 | SALTS OF (S)-(5-CYCLOBUTOXY-2-METHYL-6-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)-3,4-DIHYDROQUINOLIN-1(2H)-YL)(CYCLOPROPYL)METHANONE AND SOLID FORMS THEREOF | Forma Therapeutics, Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-107666905-A | Methods and compositions for intravenous administration of fumarate for the treatment of neurological diseases | 比奥根玛公司 | 2018-02-06 | — | — | CN | disclosed |
| CN-101641328-B | Polymorphs of N-hydroxy-3- [4- [ [ [2- (2-methyl-1H-indol-3-yl) ethyl ] amino ] methyl ] phenyl ] -2E-2-propenamide | NOVARTIS AG | 2012-10-10 | — | — | CN | disclosed |
| CN-102584673-A | Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |
| CN-101466672-B | Salts of N-hydroxy-3- [4- [ [ [2- (2-methyl-1H-indol-3-yl) ethyl ] amino ] methyl ] phenyl ] -2E-2-propenamide | NOVARTIS AG | 2012-05-16 | — | — | CN | disclosed |
| CN-101641328-A | Polymorphs of N-hydroxy-3- [ 4- [ [ [ 2- (2-methyl-1H-indol-3-yl) ethyl ] amino ] methyl ] phenyl ] -2E-2-propenamide | NOVARTIS AG CH | 2010-02-03 | — | — | CN | disclosed |
| CN-101466672-A | Salts of N-hydroxy-3- [ 4- [ [ [ 2- (2-methyl-1H-indol-3-yl) ethyl ] amino ] methyl ] phenyl ] -2E-2-propenamide | NOVARTIS AG (CH) | 2009-06-24 | — | — | CN | disclosed |
| CN-101466673-A | Process for the preparation of salts of N-hydroxy-3- [ 4- [ [ [ 2- (2-methyl-1H-indol-3-yl) ethyl ] amino ] methyl ] phenyl ] -2E-2-propenamide | NOVARTIS AG (CH) | 2009-06-24 | — | — | CN | disclosed |
| WO-2008096369-A2 | PHARMACEUTICAL FORMULATION FOR USE IN HIV THERAPY | MATRIX LABORATORIES LIMITED (IN) | 2008-08-14 | — | — | WO | disclosed |
| CN-101175748-A | N, N-substituted 3-aminopyrrolidine compounds useful as monoamine reuptake inhibitors | OTSUKA PHARMA CO LTD (JP) | 2008-05-07 | — | — | CN | disclosed |
| CN-1298391-A | 1-[(1-substituted-4-piperidinyl) methyl]-4-piperidine derivatives, process for producing the same medicinal compositions containing the same and intermediate of these compounds | DAINIPPON PHARMACEUTICAL CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| CN-1183765-A | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | SOD CONSEILS RECH APPLIC (FR) | 1998-06-03 | — | — | CN | disclosed |
| CN-1024017-C | Middle distillate compositions with improved low temperature properties | EXXON RESEARCH ENGINEERING CO (US) | 1994-03-16 | — | — | CN | disclosed |
| CN-85104295-A | Middle distillate composition with improved cold flow | — | 1986-12-03 | — | — | CN | disclosed |
| CN-85104292-A | Middle distillate compositions having improved low temperature | — | 1986-12-03 | — | — | CN | disclosed |
| US-4107391-A | ULTRAVIOLET CURING OF A SOLVENTLESS POLYESTER OR ACRYLIC RESIN COATING | GENERAL ELECTRIC COMPANY (US) | 1978-08-15 | — | — | US | disclosed |