Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.59 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484325 | 0.86 | CTSL (0.56) | PARP1LMNACYP3A4TNKSPARP15 | |
| SCHEMBL18155132 | 0.86 | CTSL (0.56) | PARP1LMNACYP3A4TNKSPARP15 | |
| SCHEMBL201369 | 0.85 | MAOB (0.58) | PARP1PARP15PARP14PARP10 | |
| SCHEMBL30239922 | 0.85 | LMNA (0.63) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL28870970 | 0.85 | MEN1 (0.73) | PARP1CYP3A4TNKSPARP15PARP14 | |
| SCHEMBL3141164 | 0.85 | LMNA (0.63) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL16952895 | 0.85 | LMNA (0.63) | PARP1LMNACYP3A4MEN1KMT2A | |
| Hydrazine SCHEMBL8166461 | 0.84 | LMNA (0.64) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL258461 | 0.83 | LMNA (0.68) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL29492631 | 0.83 | LMNA (0.68) | LMNACYP3A4MEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017628-B2 | Pharmaceutically active sulfonyl hydrazide derivatives | MERCK SERONO S.A. (CH) | 2011-09-13 | — | — | US | disclosed |
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-01-01 | — | — | US | disclosed |
| US-7432286-B1 | Pharmaceutically active sulfonyl hydrazide derivatives | LABORATORIES SERONO SA (CH) | 2008-10-07 | — | — | US | disclosed |
| EP-1216245-B1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2004-05-26 | — | — | EP | disclosed |
| EP-1216245-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023382-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | disclosed |
| EP-1088822-A1 | Pharmaceutically active sulfonyl hydrazide derivatives | Applied Research Systems ARS Holding N.V. (AN) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | SLC5A1, SLC5A2, IAPP | PARP1 3416/4885LMNA 3499/4885CYP3A4 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.