Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.43 |
| ▸ | ITGAV | P06756 | 8/20 | 0.43 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 5/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.43 |
| ▸ | ITGA8 | P53708 | 4/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25624404 | 0.89 | MEN1 (0.36) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL24036817 | 0.89 | ITGB3 (0.34) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL24036714 | 0.89 | ITGB3 (0.43) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL25624219 | 0.86 | NOTUM (0.41) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL30546801 | 0.86 | NOTUM (0.41) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL24036750 | 0.86 | GPR139 (0.50) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL25624406 | 0.85 | ITGB3 (0.39) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL25753874 | 0.85 | MAPT (0.39) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL24037106 | 0.84 | GPR139 (0.40) | ITGB3ITGAVITGB6ITGB5ITGB1 | |
| SCHEMBL24036824 | 0.83 | ITGB3 (0.40) | ITGB3ITGAVITGB6ITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | disclosed |
| WO-2021230325-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | 宇部興産株式会社 | 2021-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | ITGB3 4177/4885ITGAV 4406/4885ITGB6 3068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.