Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895132 | 0.99 | ACHE (1.00) | ACHE | |
| Iodide SCHEMBL17313355 | 0.98 | ACHE (0.98) | ACHE | |
| Hydrochloric Acid SCHEMBL2331841 | 0.98 | ACHE (0.98) | ACHE | |
| Bromide SCHEMBL6752673 | 0.90 | ACHE (0.81) | ACHE | |
| Bromide SCHEMBL6750163 | 0.89 | ACHE (0.81) | ACHE | |
| Bromide SCHEMBL6751898 | 0.89 | ACHE (0.81) | ACHE | |
| Bromide SCHEMBL2329553 | 0.89 | ACHE (0.81) | ACHE | |
| Bromide SCHEMBL6752671 | 0.89 | ACHE (0.80) | ACHE | |
| SCHEMBL15700137 | 0.89 | ACHE (0.80) | ACHE | |
| Bromide SCHEMBL6752633 | 0.88 | ACHE (0.78) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | claimed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | claimed |
| JP-11263774-A | — | — | None | — | — | JP | disclosed |
| US-11160785-B2 | Methods and compositions for improving cognitive function | AGENEBIO INC. (US) | 2021-11-02 | — | — | US | disclosed |
| CN-112641773-A | Composition containing heterocyclic compound and use thereof | 黄泳华 | 2021-04-13 | — | — | CN | disclosed |
| CN-111265524-A | Compositions containing mixtures of indene or indane derivatives and uses thereof | 黄泳华 | 2020-06-12 | — | — | CN | disclosed |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2018-01-18 | — | — | US | disclosed |
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | AGENEBIO, INC. | 2016-09-22 | — | — | US | disclosed |
| EP-2533645-B1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2016-07-27 | — | — | EP | disclosed |
| EP-1954676-B1 | PROCESS FOR MAKING DONEPEZIL | SYNTHON BV (NL) | 2012-11-07 | — | — | EP | disclosed |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-01 | — | — | US | disclosed |
| EP-1654230-A1 | PREPARATION OF INTERMEDIATES FOR ACETYL CHOLINESTERASE INHIBITORS | Hetero Drugs Limited (IN) | 2006-05-10 | — | — | EP | disclosed |
| US-20060041140-A1 | 5,6-dimethoxy-2-(4-pyridyl)methyl-1-indanone is hydrogenated using platinum oxide catalyst in the presence of hydrochloric acid under a pressure of 2 bars to give 4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride | HETERO DRUGS LIMITED (IN) | 2006-02-23 | — | — | US | disclosed |
| US-20050124642-A1 | (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds | EISAI CO., LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| EP-1047674-B1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | EISAI CO LTD (JP) | 2005-03-30 | — | — | EP | disclosed |
| WO-2005003092-A1 | PREPARATION OF INTERMEDIATES FOR ACETYL CHOLINESTERASE INHIBITORS | HETERO DRUGS LIMITED (IN) | 2005-01-13 | — | — | WO | disclosed |
| US-6706741-B2 | ALZHEIMER*S DISEASE | EISAI CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1285656-A1 | ACETYLCHOLINESTERASE INHIBITORS CONTAINING 1-BENZYL- PYRIDINIUM SALTS | Eisai Co., Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
| US-6252081-B1 | REDUCING OF THE COORRESPONDING QUATERNARY AMMONIUM SALT | EISAI CO., LTD. (JP) | 2001-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, BACE1, GRIN2A | ACHE 4/4885 |
| US-20030069289-A1 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts | ACHE, CHRM1, BCHE | ACHE 1/4885 |
| US-11160785-B2 | Methods and compositions for improving cognitive function | BACE2, BACE1, GRIN2A | ACHE 4/4885 |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ACHE 3/4885 |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ACHE 3/4885 |
| US-20060041140-A1 | 5,6-dimethoxy-2-(4-pyridyl)methyl-1-indanone is hydrogenated using platinum oxide catalyst in the presence of hydrochloric acid under a pressure of 2 bars to give 4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride | ACHE, IDH2, IMPDH2 | ACHE 1/4885 |
| US-20050124642-A1 | (1-Indanone)-(1,2,3,6-tetrahydropyridine) compounds | SIGMAR1, CHRM1, ACHE | ACHE 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.