Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17771905 | 0.78 | GAA (0.37) | MAPTALDH1A1GAAKDM4EGLA | |
| SCHEMBL21075951 | 0.74 | PKM (0.39) | MAPTALDH1A1GAAKDM4EGLA | |
| SCHEMBL18869429 | 0.74 | GAA (0.36) | MAPTALDH1A1GAAKDM4EGLA | |
| SCHEMBL14191236 | 0.71 | PRKCI (0.46) | MAPTALDH1A1GAAKDM4EGLA | |
| SCHEMBL12352662 | 0.71 | GAA (0.37) | MAPTTSHRALDH1A1GAAKDM4E | |
| SCHEMBL11412178 | 0.71 | MEN1 (0.58) | MAPTALDH1A1MEN1KMT2AGFER | |
| SCHEMBL19575431 | 0.70 | KDM4E (0.32) | TSHRALDH1A1GAAKDM4EGLA | |
| SCHEMBL19403881 | 0.69 | MEN1 (0.45) | ALDH1A1GAAKDM4EGLAPKM | |
| SCHEMBL3367619 | 0.69 | MAP2K2 (0.40) | GAAKDM4EMEN1KMT2AHPGD | |
| SCHEMBL18754812 | 0.67 | ALDH1A1 (0.45) | MAPTALDH1A1GAAKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021229302-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-11-18 | — | — | WO | disclosed |