Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22624427 | 0.86 | CYP1A2 (0.38) | PKMCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL17771905 | 0.79 | GAA (0.37) | PKMCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL23969324 | 0.79 | PLK1 (0.40) | L3MBTL1ALDH1A1HDAC6PLK1 | |
| SCHEMBL18754812 | 0.79 | ALDH1A1 (0.45) | PKMCYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL20274421 | 0.76 | KDM4E (0.48) | SMN1; SMN2KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL18869429 | 0.75 | GAA (0.36) | PKMMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL21022065 | 0.74 | RAB9A (0.41) | CYP2C9CYP2C19MEN1KMT2ALMNA | |
| SCHEMBL14404043 | 0.74 | ALOX15 (0.45) | PKMSMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL22672825 | 0.74 | LOXL2 (0.37) | PKMSMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL24038403 | 0.74 | MAPT (0.36) | PKMMEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165232-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-08-29 | — | — | WO | disclosed |
| EP-3057949-B1 | SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-05 | — | — | EP | disclosed |