Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPD1 | P10809 | 1/20 | 0.81 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.81 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | NSD2 | O96028 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403960 | 1.00 | HSPD1 (0.81) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL2403963 | 1.00 | HSPD1 (0.81) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL5455211 | 0.90 | HSPD1 (0.85) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL5455212 | 0.90 | HSPD1 (0.85) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL14788063 | 0.89 | HSPD1 (0.76) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL2489942 | 0.87 | DUSP26 (0.73) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL14788077 | 0.87 | DUSP26 (0.73) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL12637130 | 0.87 | DUSP26 (0.73) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL2489941 | 0.87 | DUSP26 (0.73) | HSPD1HSPE1DUSP26MEN1KMT2A | |
| SCHEMBL10035969 | 0.85 | MEN1 (0.73) | HSPD1HSPE1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190022100-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TRANA DISCOVERY INC (US) | 2019-01-24 | — | — | US | disclosed |
| US-10098887-B2 | Antiviral compounds and methods of use thereof | TRANA DISCOVERY, INC. (US) | 2018-10-16 | — | — | US | disclosed |
| EP-2891649-B1 | Prolylhydroxylase inhibitors and methods of use | UNIV CORNELL (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9505741-B2 | Prolylhydroxylase inhibitors and methods of use | CORNELL UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-9505741-B2 | Prolylhydroxylase inhibitors and methods of use | CORNELL UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160129006-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TRANA DISCOVERY INC (US) | 2016-05-12 | — | — | US | disclosed |
| US-20160129006-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TRANA DISCOVERY INC (US) | 2016-05-12 | — | — | US | disclosed |
| US-9173886-B2 | Antiviral compounds and methods of use thereof | TRANA DISCOVERY, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173886-B2 | Antiviral compounds and methods of use thereof | TRANA DISCOVERY, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173886-B2 | Antiviral compounds and methods of use thereof | TRANA DISCOVERY, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| EP-2891649-A1 | Prolylhydroxylase inhibitors and methods of use | Cornell University (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-2891649-A1 | Prolylhydroxylase inhibitors and methods of use | Cornell University (US) | 2015-07-08 | — | — | EP | disclosed |
| US-20130071353-A1 | Antiviral Compounds and Methods of Use Thereof | TRANA DISCOVERY, INC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130071353-A1 | Antiviral Compounds and Methods of Use Thereof | TRANA DISCOVERY, INC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130071353-A1 | Antiviral Compounds and Methods of Use Thereof | TRANA DISCOVERY, INC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130023528-A1 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | CORNELL UNIVERSITY (US) | 2013-01-24 | — | — | US | disclosed |
| US-20130023528-A1 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | CORNELL UNIVERSITY (US) | 2013-01-24 | — | — | US | disclosed |
| EP-2536709-A2 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | Cornell University (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011113060-A2 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TRANA DISCOVERY, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
| WO-2011106226-A2 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | CORNELL UNIVERSITY (US) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10098887-B2 | Antiviral compounds and methods of use thereof | TYMP, MAVS, ZC3HAV1 | HSPD1 2879/4885HSPE1 2494/4885DUSP26 2061/4885 |
| US-20160129006-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TYMP, MAVS, ZC3HAV1 | HSPD1 2879/4885HSPE1 2494/4885DUSP26 2061/4885 |
| US-20130071353-A1 | Antiviral Compounds and Methods of Use Thereof | TYMP, MAVS, ZC3HAV1 | HSPD1 2879/4885HSPE1 2494/4885DUSP26 2061/4885 |
| US-20190022100-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF | TYMP, MAVS, ZC3HAV1 | HSPD1 2879/4885HSPE1 2494/4885DUSP26 2061/4885 |
| US-20130023528-A1 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | EGLN3, HIF1AN, EGLN2 | HSPD1 353/4885HSPE1 192/4885DUSP26 1816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.