Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 19/20 | 0.44 |
| ▸ | THRB | P10828 | 19/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12182692 | 0.71 | THRA (0.50) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL22643888 | 0.65 | THRB (0.40) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL22668218 | 0.64 | THRB (0.67) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL12182720 | 0.64 | THRB (0.46) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL15578029 | 0.64 | THRB (0.80) | THRATHRB | |
| SCHEMBL22632428 | 0.63 | THRA (0.66) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL21749523 | 0.63 | THRA (0.67) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL2926289 | 0.63 | THRB (0.67) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL21749414 | 0.63 | THRA (0.67) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL14628110 | 0.62 | THRA (0.83) | THRATHRBCYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689853-B1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS INC (US) | 2021-11-24 | — | — | EP | disclosed |