Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of P-Cymene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Cymene SCHEMBL27525277 | 0.93 | CYP2C9 (0.50) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL1073347 | 0.92 | ACHE (0.47) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL27355344 | 0.92 | ACHE (0.47) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL28238347 | 0.91 | ALOX5 (0.55) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL29129736 | 0.88 | ACHE (0.47) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL1292882 | 0.87 | ACHE (0.47) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| Terephthalic Acid SCHEMBL15994297 | 0.87 | ALDH1A1 (0.71) | CYP2C9USP5ALDH1A1SMN1; SMN2SCN5A | |
| P-Cymene SCHEMBL27582590 | 0.87 | KDM4E (0.53) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| P-Cymene SCHEMBL1143 | 0.87 | ACHE (0.53) | ACHEALOX5SCN5ASCN2ATYR | |
| P-Cymene SCHEMBL1697748 | 0.87 | ACHE (0.53) | ACHEALOX5SCN5ASCN2ATYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110229814-A1 | TONER, METHOD OF MANUFACTURING TONER, AND IMAGE FORMING METHOD USING TONER | RICOH COMPANY, LTD. (JP) | 2011-09-22 | — | — | US | disclosed |